We are a research group from the London School of Hygiene and Tropical Medicine

The purpose of this project is to map the geographical distribution of resistance mutations in African Plasmodium falciparum malaria. We have reviewed all genetic studies of resistance to Sulphadoxine Pyrimethamine (also known as ‘SP’ or ‘Fansidar’) in parasites sampled from infected people living in clearly identified geographical sites in Africa. Static maps which summarise the distribution of particular mutations have been published (Lynch et al 2008, Gesase et al 2009, Naidoo and Roper 2010, Naidoo and Roper 2011) and here they are available as interactive Google maps. The interactive maps are regularly updated and so they incorporate studies that have become available since publication these papers.

Literature review

We conducted a review of published studies using the online databases Pubmed, African Journal Online and Bioline. Electronic searches using the terms: "malaria" "dhfr" "dhps" or "540" or "437" or "436" or "581" or 51 or 59 or 108 or 164 were carried out between October 2005 to February 2011. To be included, studies had to include analysis of dhfr or dhps genes in P. falciparum isolates sampled from infected people living in a clearly identified geographical site in Africa.

Mapping

We attached a longitude and latitude to each study site and plotted these data on Google maps for each of a number of the key mutations. In the maps the user can zoom in or out, or select by country. Each record on the map records: the number of samples tested and the number found positive for that particular mutation, the year of sample collection, the author and year of the publication and a link to the online publication source. For studies where we could not ascertain the year of sampling, the year of publication is given (eg <2005). ‘Prevalence’ is the proportion of the total number of samples tested in which the mutation was detected. We have colour coded map pins into five prevalence categories namely 0 (white),1-25% (blue), 26-50% (green), 51-75% (brown) and 76-100% (red). Lowongan Kerja Jakarta

Meet the team
cally roper

Cally Roper

Senior Lecturer at the LSHTM

The emergence and spread of drug resistance is a major threat to effective treatment of malaria. Understanding of the geographic dispersal of resistance in Africa provides a framework for the optimal use of treatment interventions and the strategic management of resistance. Cally's research is on the genetics of malaria parasites and their vectors, and most recently she has worked on practical questions surrounding the treatment of P. falciparum malaria and how this impacts on resistance evolution.

inbarani naidoo

Inbarani Naidoo

Completing a PhD degree at LSHTM.

Maps play an increasingly important role in coordinating malaria control activities. Here they are used as a tool to track the spatial extent and temporal patterns of SP resistance mutations across the African continent. Inbarani’s research interests are geographic information systems, epidemiology and antimalarial resistance. Her focus is on collecting antimalarial resistance data to track its distribution in Africa. Her research involves collaboration with LSHTM and partners in Africa.

database team, Inbarani Naidoo – seated first from left, Ntombifikile Mbatha – standing second from left, Liezel Fisher – seated second from right, Dayanandan Govender – first from right

The database team

The database team are based at the Malaria Research Programme and together they maintain the data in a relational database within the framework of the Mapping Malaria Risk in Africa (MARA) Project. Dayanandan programs the database and data validation systems. Ntombifikile and Liezel capture data from the proformas and clean the data.

  • Inbarani Naidoo – seated first from left
  • Ntombifikile Mbatha – standing second from left
  • Liezel Fisher – seated second from right
  • Dayanandan Govender – first from right